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What is the reaction of alcohol with colorectal cancer?

Colon and rectum are two of the main organs which make up the digestive system, mainly the large intestine. Any problems persisting in any of these organs may result in the malfunctioning of the digestive system.

Colorectal cancer is one such disease which highly affects the rectum and the colon. When the cells in the inner lining of the rectum and the colon start multiplying even when there is no need for multiplication, it gives rise to colorectal cancer.

This is caused mainly due to the abnormal growth of the cells in the rectum and the colon. Colorectal cancer can be very dangerous if not treated at the correct time and in the correct manner. It is the third most common death causing cancer in the world.

There are various risk factors which may lead to colorectal cancer in a person. These risk factors include family history of colorectal cancer i.e. hereditary problem, age factor, smoking and many more. Another very common risk factor of the colorectal cancer is the intake of alcohol. You must be wondering how alcohol can affect the rectum and the colon. This article will tell you the reason why alcohol can prove to be dangerous to you colon and the rectum.

Alcohol has both positive as well as negative effect on the cells of the rectum and colon. As a positive effect, alcohol can lead to the death of the cancerous cells which are growing inside the organs but as a negative effect it may stimulate the proliferation of the cancerous cells. Studies have clearly shown that the risk of colorectal cancer in a person increases with the increase in his alcohol drinking habit. More the intake of alcohol more will be the person at the risk of colorectal cancer.

Studies have been made regularly regarding this aspect and they have shown that the people consuming around or more than 30 grams of alcohol per day are at an increased risk of colorectal cancer than those who do not drink at all.

The people who have an intake of more than 45 grams of alcohol per day are at the maximum risk of colorectal cancer. Also it has been proved that about 3.6 % of colorectal cancer cases are due to alcohol intake and the 3.5 % of the deaths due to colorectal cancer have drinkers involved.

In a research done for about 14 years and 7 months it was shown that out of 400 cases of colorectal cancer about half of the people were at the regular intake of alcohol.People who had 41 drinks per week had 95 % chances of suffering from colorectal cancer.

Alcohol is considered to be dangerous because it stimulates the growth of adenoma and as a result promotes colorectal carcinogenesis. It has been shown by various studies and researches that out of all the drinks containing alcohol, beer is the drink which is closely associated with the risk of colorectal cancer whereas wine has the weakest association.

Alcohol tends to alter the metabolism process of the liver compounds like the genotoxic compounds (eg: nitrosamines). This is because the microsomal monooxygenase i.e. the metabolism system of the liver is suppressed by the intake of alcohol and this as a result leads to the growth of colorectal cancer.

The risk of colorectal cancer due to alcohol intake depends on various factors like the amount of alcohol intake per day, the type of alcohol intake etc. On one hand when studies show that beer can increase the risk of colorectal cancer in a person it has also been proved on the other hand that the moderate intake of wine can reduce the risk of colorectal cancer.

In conclusion, it can be said that alcohol is moderately related with the risk of colorectal cancer.

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