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How is non alcoholic fatty liver disease diagnosed?

Liver disease is also called hepatic disease. This is in terms of group of single number of diseases affecting the liver.

Non-alcoholic fatty liver disease is a liver disease.
– This is one cause of a fatty liver.
– This occurrs when fat is deposited (steatosis) in the liver.
– It is not due to excessive alcohol use.
– It is related to insulin resistance and the metabolic syndrome.
– This is involved with symptoms such as weight loss, metformin and thiazolidinediones.
– Non-alcoholic steatohepatitis (NASH) is the most extreme form of NAFLD.
– This is regarded as a major cause of cirrhosis of the liver of unknown cause.

Causes of Non Alcoholic Fatty Liver Disease
– Fatigue
– Malaise
– Dull right-upper-quadrant abdominal discomfort
– Mild jaundice
– Abnormal liver function tests
– Alcohol consumption of over 20 g/day
– Insulin resistance
– Metabolic syndrome
– Obesity
– Combined hyperlipidemia
– Diabetes mellitus (type II)
– High blood pressure

Secondary Causes
NAFLD can also be caused by some medications.
– Amiodarone
– Antiviral drugs (nucleoside analogues)
– Aspirin rarely as part of Reye’s syndrome in children
– Corticosteroids
– Methotrexate
– Tamoxifen
– Tetracycline

Diagnosis of Non Alcoholic Fatty Liver Disease
– Elevated liver enzymes
– A liver ultrasound showing steatosis.
– An ultrasound may also be used to exclude gallstone problems (cholelithiasis).
– Computed Tomography (CT) —a method of body imaging in which a thin X-ray beam rotates around the patient which provides a detailed view of the liver.
– A biopsy (tissue examination) of the liver is the only test widely accepted.
– FibroTest that estimates liver fibrosis.
– SteatoTest that estimates steatosis.
– Apoptosis has been shown to be the mechanism of hepatocyte destruction and caspase-cleaved cytokeratin 18 (M30-Apoptosense ELISA) in serum/plasma.

Relevant Blood Tests
– Erythrocyte sedimentation rate
– Glucose
– Albumin
– Renal function
– Coagulation related studies
– The INR (international normalized ratio)

Blood tests (serology) are usually used to rule out:
– Viral hepatitis (hepatitis A, B, C, EBV, CMV andherpes viruses),
– Rubella,
– Autoimmune related diseases
– Hypothyroidism

Diagnosis
– Abdominal Ultrasound
– AMA Test
– ERCP (Endoscopic Retrograde Cholangiopancreatography)
– Liver Biopsy
– Liver Panel
– Manifestations of Liver Disease
– Needle Biopsy

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