Categories

A sample text widget

Etiam pulvinar consectetur dolor sed malesuada. Ut convallis euismod dolor nec pretium. Nunc ut tristique massa.

Nam sodales mi vitae dolor ullamcorper et vulputate enim accumsan. Morbi orci magna, tincidunt vitae molestie nec, molestie at mi. Nulla nulla lorem, suscipit in posuere in, interdum non magna.

Alcoholic Liver Disease – Part 2

• Alcoholic liver disease is a condition which contributes to the hepatic manifestations of over consumption of alcohol.
• Alcohol is the basic reason for the rise of liver disease especially in Western countries.
• Although steatosis (fatty liver) will build up in a person who consumes a large level of alcohol based drinks spanning a long time, this is transient and reversible.

Risk factors for Alcoholic Liver Disease

Alcoholic Hepatitis
• Alcoholic hepatitis is considered as the soreness of hepatocytes.
• Between 10% and 35% of heavy drinkers develop alcoholic hepatitis.
• While development of hepatitis is not proportional towards dose of alcohol, a number of people seem more prone to this reaction than others.
• This is known as alcoholic steato necrosis.
• The inflammation looks like to be predisposed to liver fibrosis.
• Inflammatory cytokines like TNF-alpha, IL6 and IL8 are required for the induction and perpetuation of injury of the liver.
• This is done by inducing apoptosis and necrosis.
• One possible mechanism of the increased activity of TNF-α is the increased intestinal permeability on account of liver disease.
• This facilitates the absorption in the gut-produced endotoxin in the portal circulation.
• The Kupffer cells in the liver then phagocytose endotoxin, stimulating the release of TNF-α.
• TNF-α then triggers apoptotic pathway throughout the activation of caspases, producing cell death.

Cirrhosis
• Cirrhosis is a serious liver disease which is at a later stage. It is marked by:
– Inflammation
– Fibrosis
– Damaged membranes preventing detoxification of chemicals in the body
– Ending in scarring
– Necrosis
• 10% to twenty% of heavy drinkers will develop cirrhosis of the liver.
• Acetaldehyde will lead to alcohol-induced fibrosis which occurs by collagen deposition which is done by hepatic stellate cells.
• Producing oxidants produced by NADPH Oxi- dase or cytochrome P-450 2E1
• The development of acetaldehyde-protein adducts damage the cell membrane.
Symptoms include:
– Jaundice
– Liver enlargement
– Pain
– Tenderness
– Morphological changes in damaged liver architecture.

Late complications of cirrhosis or liver failure include:
– Portal hypertension portal vein
– Coagulation disorders
– Ascites
– Hepatic encephalopathy
– The hepatorenal syndrome
• Cirrhosis also can be a consequence of other causes than alcohol abuse, for instance viral hepatitis and heavy contact with toxins other than alcohol.
• The late stages of cirrhosis may look similar medically, in spite of cause.
• This phenomenon is termed the “final common pathway” with the disease.
• Fatty change and alcoholic hepatitis with abstinence might be reversible.
• The later stages of fibrosis and cirrhosis usually are irreversible, but not usually be contained with abstinence for a long time.

Diagnosis of Alcoholic Liver Disease

• There are several tests to assess alcoholic liver damage.
• Besides blood examination, physicians use ultrasound as well as a CT scan to assess liver damage.
• In some instances a liver biopsy is completed.
• This minor procedure is completed under local anesthesia.
• It calls for putting a small needle inside the liver and receiving a slice of tissue.
• The tissue is then sent to the laboratory for being examined within the microscope.

The differential diagnosis is wide.
• Fatty liver non-alcoholic steatosis
• Drug-induced steatosis
• Diabetes
• Obesity
• Starvation

Alcoholic Liver Disease Dr. Melissa Palmer’s Guide To Hepatitis and Liver Disease The Liver Cleansing Diet

Leave a Reply

You can use these HTML tags

<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>