Posts Tagged ‘Risk Factors’

How can we prevent and diagnose Osteoporosis

May 17th, 2010

To reach optimal peak bone mass and continue building new bone tissue as you age, you should consider several factors.
- Calcium: An inadequate supply of calcium over a lifetime contributes to the development of osteoporosis. Food sources of calcium include low-fat dairy products, such as milk, yogurt, cheese, and ice cream; dark green, leafy vegetables, such as broccoli, collard greens, bok choy, and spinach; sardines and salmon with bones; tofu; almonds; and foods fortified with calcium, such as orange juice, cereals, and breads.
- Vitamin D: Vitamin D plays an important role in calcium absorption and bone health. It is synthesized in the skin through exposure to sunlight. Food sources of vitamin D include egg yolks, saltwater fish, and liver.
- Smoking: Women who smoke have lower levels of estrogen compared with nonsmokers, and they often go through menopause earlier. Smokers also may absorb less calcium from their diets.
- Exercise: Like muscle, bone is living tissue that responds to exercise by becoming stronger. Weight-bearing exercise is the best for your bones because it forces you to work against gravity.
- Alcohol: Regular consumption of 2 to 3 ounces a day of alcohol may be damaging to the skeleton, even in young women and men.
- Medications that cause bone loss: The long-term use of glucocorticoids (medications prescribed for a wide range of diseases, including arthritis, asthma, Crohn’s disease, lupus, and other diseases of the lungs, kidneys, and liver) can lead to a loss of bone density and fracture.

Diagnosis of Osteoporosis

Women who have had a fracture due to fragility are diagnosed with severe osteoporosis and have a high risk for another fracture. Early diagnosis can prevent fractures and slow deterioration of bone tissue.
If the doctor suspects osteoporosis, a bone scan would be suggested. – A common test that measures bone density is called a dual energy X-ray absorptiometry (DEXA). This test measures the density of the bones in your hips, spine and wrist, which are all places likely to be affected by osteoporosis.
- Quantitative computed tomography (QCT) measures bone density in the hip and spine and produces a three-dimensional image that shows true volume density. QCT has the capacity to isolate an area for testing. The radiation level in QCT is 10 times higher than in DEXA.
- Peripheral bone density testing uses ultrasound to identify bone loss in a localized area such as the heel or hand.
Doctor may also order an ultrasound or a computerized tomography (CT) scan to help check the density of your bones.

What is osteoporosis and what are the signs and symptoms of osteoporosis ?

May 16th, 2010

Osteoporosis is a disease characterized by low bone mass and loss of bone tissue that may lead to weak and fragile bones. Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone micro architecture is disrupted, and the amount and variety of proteins in bone is altered.
Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men.

Causes of Osteoporosis

- Osteoporosis occurs when there is an imbalance between new bone formation and old bone resorption.
- The body may fail to form enough new bone, or too much old bone may be reabsorbed, or both.
- The leading cause of osteoporosis is a lack of certain hormones, particularly estrogen in women and androgen in men.
- Other factors that may contribute to bone loss in this age group include inadequate intake of calcium and vitamin D, lack of weight-bearing exercise, and other age-related changes in endocrine functions.

Symptoms of Osteoporosis

Osteoporosis can be present without any symptoms for decades because osteoporosis doesn’t cause symptoms until bone fractures. he symptom associated with osteoporotic fractures usually is pain; the location of the pain depends on the location of the fracture.

Risk factors of Osteoporosis

- Getting older.
- Being small and thin.
- Having a family history of osteoporosis.
- Taking certain medicines.
- Being a white or Asian woman.
- Having osteopenia, which is low bone mass.
- Cigarette smoking, eating disorders such as anorexia nervosa or bulimia, low amounts of calcium in the diet, heavy alcohol consumption, inactive lifestyle, and use of certain medications, such as corticosteroids and anticonvulsants, are also risk factors.
- Rheumatoid arthritis itself is a risk factor for osteoporosis.

Facts and Figures

- Osteoporosis is a major public health threat for 44 million Americans, 68 percent of whom are women.
- One out of every two women and one in four men age 50 and older will have an osteoporosis-related fracture in their lifetime.
- Osteoporosis can strike at any age.
- Osteoporosis is responsible for more than 1.5 million fractures annually, including approximately 300,000 hip fractures, 700,000 vertebral fractures, 250,000 wrist fractures, and more than 300,000 fractures at other sites.

Chronic myelogenous leukemia (CML) – Overview

April 16th, 2010

Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.

Causes and Risk factors

Children of parents with CML do not have a greater risk of developing the disease. There is a question as to whether radiation used for treatment raises the risk of CML. No infectious agents are linked to the development of this leukemia.

Symptoms

During the early stages of CML most people do not have any symptoms of the disease. When symptoms do develop they include:
– Tiredness that will not go away.
– Unexplained weight loss.
– Fever.
– Shortness of breath.
– Night sweats.
– Abdominal pain from a swollen spleen.
– Poor appetite.
People who have any of these symptoms should consult with their doctor. None of these symptoms prove that a person has cancer or leukemia and a true diagnosis can be made only by a trained oncologist or hematologist.

Phases of CML

CML is divided into three phases depending on the maturity of the leukemia WBCs.
- Chronic phase
There are mostly mature leukemia WBCs in the blood and bone marrow and there may be no symptoms of leukemia. This phase lasts from several months to several years, with an average duration of five years.
- Accelerated phase
There are some immature leukemia WBCs in the blood and bone marrow (between 5 percent and 30 percent). Patients may have fever, poor appetite and weight loss. The leukemia cells may have new chromosome changes, in addition to the Philadelphia chromosome.
- Acute phase
It is also called blast phase or blast crisis. In this phase, there are mostly immature WBCs in the blood and bone marrow (more than 30 percent). Symptoms such as anemia and recurring infections are typical.

How is CML treated?

Treatment options for people with CML depend on the phase of their disease, age and the availability of a potential donor for a bone marrow or blood cell transplant.
- Chemotherapy : It uses drugs to kill cancer cells. These drugs are usually taken by mouth or administered in a vein or into the skin or tissue. Because the drugs circulate in the blood, they can reach leukemia cells all over the body. There are four drugs used in the treatment of chronic phase CML.
- Immune therapy : It uses the body’s immune system to fight cancer. One type used to treat chronic phase CML is interferon alpha, a regulator of the immune system. Interferon alpha is sometimes combined with cytarabine chemotherapy and can be associated with adverse side effects, some of which are severe.
- Bone marrow transplantation : It is used to replace the CML patient’s unhealthy bone marrow (which produces abnormal blood cells) with healthy bone marrow (that can produce normal blood cells).

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