Posts Tagged ‘Ultrasound’

How is liver cancer diagnosed?



Liver cancer is also known as hepatocellular carcinoma, HCC. It is a cancer that originates in liver. Liver cancers are malignant tumors that grow on the surface or inside the liver.

Diagnosis of Liver Cancer

Blood Tests
- Liver cancer depends so much on the vigilance of the physician screening with a tumor marker (alpha-fetoprotein) in the blood and radiological imaging studies.
- If the blood tests become abnormal or worsen due to liver cancer, this usually signifies extensive cancerous involvement of the liver.
- in liver cancer, the cancerous liver cells may take on the characteristics of other types of cells.
- For example, liver cancer cells sometimes can produce hormones that are ordinarily produced in other body systems.
- These hormones then can cause certain abnormal blood tests
- These include a high red blood count (erythrocytosis), low blood sugar (hypoglycemia) and high blood calcium (hypercalcemia).
- High serum cholesterol (hypercholesterolemia), is seen in up to 10% of patients from Africa with liver cancer.
- The high cholesterol occurs because the liver cancer cells are not able to turn off (inhibit) their production of cholesterol.
- There is no reliable or accurate screening blood test for liver cancer.
- The most widely used biochemical blood test is alpha-fetoprotein (AFP)
- AFP is a protein normally made by the immature liver cells in the fetus.

In adults, high blood levels (over 500 nanograms/milliliter) of AFP are seen in only three situations:
- Liver cancer.
- Germ cell tumors (cancer of the testes and ovaries).
- Metastatic cancer in the liver (originating in other organs).

There are a number of other liver cancer tumor markers like:
- Des-gamma-carboxyprothrombin (DCP),
- A variant of the gamma-glutamyltransferase enzymes,
- Variants of other enzymes (for example, alpha-L-fucosidase).

Imaging Studies
These studies provide information
- as to the size of the tumor.
- the number of tumors.
- whether the tumor has involved major blood vessels locally or spread outside of the liver.

Ultrasound Examination
- It is usually the first study ordered if liver cancer is suspected in a patient.
- The accuracy of an ultrasound depends very much on the technician and radiologist.
- Computerized axial tomography (CT scan) is a very common study used in the U.S.
- The ideal CT study is a multi-phase, spiral CT scan using oral and intravenous contrast material.

Pictures are taken in three phases:
- Without intravenous contrast.
- With intravenous contrast (enhanced imaging) that highlights the arterial system (arterial phase).
- When the contrast is in the venous phase.

Magnetic Resonance Imaging (MRI)
- It can provide very clear images of the body.
- Its advantage over CT is that MRI can provide sectional views of the body in different planes.

Others
- If there is uncertainty about the diagnosis, the presence of liver cancer may be confirmed with a biopsy.
- Tissue from the liver is removed through a needle or during an operation and checked under a microscope for the presence of cancer cells.
- Laproscopy is another method.

Staging
The following stages are used for adult primary liver cancer:
- Localized resectable
Cancer is found in one place in the liver and can be completely removed by surgery.
- Localized unresectable
Cancer is found only in one part of the liver, but the cancer cannot be totally removed.
- Advanced
Cancer has spread through much of the liver or to other parts of the body.
- Recurrent
Cancer has come back or recurred after it was treated. It may come back in the liver or in another part of the body.


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Be the first to comment - What do you think?  Posted by ashish - December 23, 2011 at 9:26 am

Categories: Body, Cancer, Cells, Complications, cure, Detection, Diagnosis, digestion, Digestive System, Disease, Disorder, growth, health, Healthy, Liver, Metabolism   Tags: , , , , , , , , , , , , , , , , , , , , , , , , ,

Adrenal Gland Cancer – Tests

Adrenal Gland cancer is a very rare type of cancer that is caused due to the excessive production of hormones in the adrenal gland. The condition can get fatal if not diagnosed in time and therefore one must pay attention to the symptoms and consult and expert if they think they could be suffering from adrenal cancer.
There are a number of ways to diagnose the condition and your expert will carry out necessary tests to check whether you are suffering from the disease. Below mentioned are a few diagnostic measures that doctors may adhere to while checking you for adrenal cancer.

Blood tests: Most doctors will ask you to get blood tests done to check the circulation of hormones in the body. Excessive production of certain hormones like cortisol, estrogen, aldosterone, testosterone are characteristic to the cancer and therefore blood tests serve as a good starting point.

However both malignant and benign tumors cause the over production of hormones and are not indicators of whether the tumor is malignant or benign. Therefore the tests are non conclusive and would need to be complimented with other tests to check the tumors
There are four X-Ray tests that are primarily used for the detection of a tumor in the adrenal gland:

Ultrasound: The ultrasound is most commonly used to examine one’s adrenal gland and kidneys. The ultrasound test however may not be as accurate as the CT Scan and therefore is not preferred as the best method to detect tumors. The test however can be used to detect any kind of adrenal tumor.

CT Scan: The CT Scan also known as the CAT Scan is another common way of examining whether a patient is suffering from adrenal cancer. It can be used to detect any type of adrenal tumor and is painless. The procedure is not long and only takes about 30 minutes. It is one of the most accurate ways of examining the adrenal glands for tumors. The pictures generated help in sizing up the tumors well that help in planning the treatments that should be taken up.
The scan identifies the following:
Left adrenal gland
Left Kidney
Pancreas
Spleen outline

MRI Scan: The MRI Scan is similar to the CAT Scan. It is also known as the MR Scan or the NMR Scan. The MRI scan takes about an hour to complete and deploys magnetic fields to produce pictures unlike x-ray like images that the CAT scan generates or sound waves that you get from an ultra sound.
Pheochromocytomas light up on an MRI Scan making it one of the most accurate ways of detecting adrenal tumors of any type.

MIBG Scan: The MIBG scan is used to detect the location and presence of adrenal pheochromocytomas. The test is ineffective in detecting other types of adrenal tumors.

Most doctors will utilize the above mentioned tests to examine your body for adrenal tumors. However it is essential that you seek the guidance of an expert when it comes to adrenal gland cancer as you need to ensure that the proper treatment is adhered to after the tumor is detected be it malignant or benign.
When you consult a doctor who is recognized you can be sure that you will receive the best treatment. Over and above medication and surgeries you need to pay attention to your diet and make efforts to stay healthy by indulging in physical exercise. The medication can lead you to feeling tired and lethargic and therefore you should try and fight the illness itself with your mind and try and keep a brave front. If you are willing to fight the disease it can be defeated.

Be the first to comment - What do you think?  Posted by ashish - August 1, 2010 at 12:29 pm

Categories: Cancer, Test   Tags: , , , , , , , , , , , , ,

Diagnosis Tests of Prostate Cancer

Prostate cancer is diagnosed from the results of a biopsy of the prostate gland. If the digital rectal exam of the prostate or the PSA blood test is abnormal, a prostate cancer is suspected. A biopsy of the prostate is usually then recommended.

Prostate-specific antigen (PSA) test

A test that measures the level of PSA in the blood. PSA is a substance made by the prostate that may be found in an increased amount in the blood of men who have prostate cancer. PSA levels may also be high in men who have an infection or inflammation of the prostate or BPH.

Digital Rectal Exam (DRE)

During this exam, the physician inserts a lubricated, gloved finger (digit) into the rectum. Because of the prostate’s location just in front of the rectum, the physician is able to feel the edge of the prostate where the majority of cancers begin. Abnormalities such as bumps or hardness of the prostate can be detected in this way.

MRI Scan

A magnetic resonance imaging (MRI) scan is a computerized picture made by magnetic fields that can show detailed, cross-sectional images of the inner body. MRI scans can create a clear picture of the prostate gland.

Ultrasound

The prostate can be examined through a type of ultrasound called transrectal ultrasonography. In this exam, a tube is inserted into the rectum that carries the sound waves to the nearby prostate, producing a better image.

CT Scan

A CT (computed tomography) scan is a sophisticated x-ray producedure that uses a computer and rotating x-ray beams to produce images of soft tissue, bone, and blood vessels.

Prostate Biopsy

If an abnormality is found on the DRE or the PSA test, the physician will typically order a biopsy of the prostate.
A biopsy involves taking a very small sample of tissue from the prostate. This is done using a thin needle that is placed into the prostate. A tiny amount of tissue is trapped in the needle while it is in the prostate and then the needle is pulled out. This procedure is usually done by an urologist or other surgeon. The pathologist will examine the biopsy sample to check for cancer cells and determine the Gleason score. The Gleason score ranges from 2-10 and describes how likely it is that a tumor will spread. The lower the number, the less likely the tumor is to spread.
There are 2 types of biopsy procedures used to diagnose prostate cancer:
- Transrectal biopsy : The removal of tissue from the prostate by inserting a thin needle through the rectum and into the prostate.
- Transperineal biopsy: The removal of tissue from the prostate by inserting a thin needle through the skin between the scrotum and rectum and into the prostate.

Be the first to comment - What do you think?  Posted by ashish - March 25, 2010 at 7:17 am

Categories: Cancer, causes, Diagnosis, Malignancy, Test   Tags: , , , , , , , , , , , , ,